CHLORPHENIRAMINE MALEATE

CHLORPHENIRAMINE MALEATE
PRODUCT IDENTIFICATION
CAS NO.	132-22-9, 42882-96-2, 46970-45-0 (base) 25523-97-1 (D-form) 56343-98-7 (hydrochloride) 113-92-8, 7054-11-7 (maleate)
EINECS NO.	205-054-0, 247-073-7
FORMULA	C₁₆H₁₉ClN₂ · C₄H₄O₄
MOL WT.	390.86
TOXICITY	Oral Rat LD50: 306mg/kg
H.S. CODE	2933.39.4100
SYNONYMS	Chlorpheniramine maleate; Polaronil; Pyridamal 100;
Chlorphenamine hydrogen maleate; Carbinoxamide maleate; Medique chlorphen; Neorestamin; DL-2-(p-Chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridine maleate; DL-Chlorpheniramine maleate; Synistamin; Teldrin; Chlor-tripolon; Chlormene; Chloroprophenpyridamine maleate; Chlorpheniramine maleate; gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine (2Z)-2-butenedioate; Chlor-trimeton;
SMILES	C(c1ccc(cc1)Cl)(c1ccccn1)CCN(C)C.C(=C\C(=O)O)\C(=O)O
CLASSIFICATION	Antihistaminic, Histamine H1 antagonist, Neurotransmitter agent, Antipruritic, Dermatologic agent
EXTRA NOTES	H₁ Histamine receptor antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than Promethazine.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT	130 - 135 C
BOILING POINT	Decomposes
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Soluble
SOLVENT SOLUBILITY
pKa	9.13 (base)
VAPOR DENSITY
log P (octanol-water)	3.38 (base)
HENRY LAW CONSTANT	4.07E-10 (atm-m3/mole at 25 C)
OH RATE CONSTANT	8.55E-11 (cm3/molecule-sec at 25 C Atmospheric)
REFRACTIVE INDEX
NFPA RATINGS	Health hazard: 2, Fire: 0, Reactivity Hazard: 0
AUTOIGNITION
FLASH POINT
STABILITY	Stable under normal conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Chlorphenamine Material Safety Data Sheet http://www.drugbank.ca/ In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. http://otcsafety.org/ Chlorpheniramine is an antihistamine active ingredient available in over-the-counter (OTC) medicines that treats hay fever or other respiratory allergies. It may be written as chlorpheniramine or chlorpheniramine maleate, but it is the same active ingredient. Chlorpheniramine can be the only active ingredient in an allergy medicine or it can be found in medicines that not only relieve allergies, but other symptoms such as body aches and pains, or symptoms associated with the common cold.
SALES SPECIFICATION
APPEARANCE	white to off-white crystalline powder
IDENTIFICATION	passes Test IR
ASSAY	98.0% - 101.0%
LOSS ON DRYING	0.5%
RESIDUE ON IGNITION	0.2%
TRANSPORTATION
PACKING
HAZARD CLASS	6.1 (Packing group: III)
UN NO.	2811
SAFETY INFORMATION
GHS
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H301 Toxic if swallowed.
PRECAUTIONARY STATEMENTS	P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
EC DIRECTIVES
HAZARD CODES
RISK PHRASES
SAFETY PHRASES
PRICE INFORMATION